Michael J. Bennett Ph.D., FRCPath, DABCC, FACB
University of Pennsylvania
Dr. Bennett is a Professor of Pathology and Laboratory Medicine at the University of Pennsylvania and Director of the Metabolic Disease laboratory at The Children’s Hospital of Philadelphia. He also holds the Evelyn Willing Bromley Endowed Chair in Clinical Laboratories and Pathology. He obtained his Ph.D. at the University of Sheffield School of Medicine, UK in the field of medical enzymology. His initial training was with the Sheffield Central Hospitals Group and the Association of Clinical Biochemists (UK). He was a Principal Biochemist at the Sheffield Children’s Hospital. He became a Member and eventually a Fellow of the Royal College of Pathologists (London). Dr Bennett’s research activities include the use of mass spectrometry in the investigation of inborn errors of mitochondrial energy metabolism with a special emphasis on disorders of fatty acid metabolism. He was amongst the first to describe the fatal clinical phenotype and subsequently the first to identify neonatal metabolite abnormalities in medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. These observations led eventually to the present expansion in expanded newborn screening by tandem mass spectrometry. Present research in this area covers study of the hyperinsulinism associated with short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) deficiency, an enzyme of fatty acid oxidation that is closely related to MCAD. Dr Bennett also performs research into the pathophysiology of Batten disease (Juvenile Neuronal ceroid-Lipofuscinosis) a devastating neurodegenerative disorder of childhood with the goal of developing rational therapy for this recessive disorder.